Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.09.003
Abstract: Compounds that modulate H2O2 reaction networks have applications as targeted cancer therapeutics, as a subset of cancers exhibit sensitivity to this redox signal. Previous studies to identify therapeutics that induce oxidants have relied upon probes… read more here.
Keywords: peroxiredoxin; h2o2 mediated; screening compound; cancer therapeutics ... See more keywords
Development of Multiwell-Plate Methods Using Pure Cultures of Methanogens To Identify New Inhibitors for Suppressing Ruminant Methane Emissions
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00396-17
Abstract: ABSTRACT Hydrogenotrophic methanogens typically require strictly anaerobic culturing conditions in glass tubes with overpressures of H2 and CO2 that are both time-consuming and costly. To increase the throughput for screening chemical compound libraries, 96-well microtiter… read more here.
Keywords: ruminant methane; throughput; methane emissions; methane ... See more keywords
Abstract 5331: DNA-encoded macrocyclic compound libraries for challenging targets
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5331
Abstract: Increasingly drug discovery programs require the development of orally available and cell permeable classes of drugs derived from the chemical space beyond Lipinski’s rule of 5 (bRO5). The chameleon-like physicochemical properties and differentiated binding modes… read more here.
Keywords: compound libraries; macrocyclic compound; dna; dna encoded ... See more keywords