The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study
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DOI: 10.18632/oncotarget.15601
Abstract: Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual… read more here.
Keywords: virtual screening; potent antitumor; compound potent; antitumor activity ... See more keywords
A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
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DOI: 10.3390/molecules27061894
Abstract: Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many… read more here.
Keywords: compound potent; helquat like; rna; potent inhibitor ... See more keywords