Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.02.021
Abstract: Covalent kinase inhibitors, which typically target cysteine residues, represent an important class of clinically relevant compounds. Approximately 215 kinases are known to have potentially targetable cysteines distributed across 18 spatially distinct locations proximal to the… read more here.
Keywords: targetable cysteines; promiscuity identify; leveraging compound; compound ... See more keywords
Evaluating the Utility of the MSTI Assay in Predicting Compound Promiscuity and Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00243
Abstract: Nonspecific reactive chemicals often interfere with the interpretation of high-throughput assay results because of their promiscuity and/or cytotoxicity. Using a high-throughput assay to identify such compounds is necessary to efficiently rule out potential assay artifacts.… read more here.
Keywords: promiscuity cytotoxicity; promiscuity; compound promiscuity; msti assay ... See more keywords