Articles with "compounds 10a" as a keyword



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Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.

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Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.104399

Abstract: In view of their DNA intercalation activities as anticancer agents, novel twenty four [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 as DNA intercalators and Top II enzyme inhibitors. The… read more here.

Keywords: dna; triazolo quinoxaline; dna intercalators; quinoxaline derivatives ... See more keywords