Multifunctional Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties.
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DOI: 10.1021/acs.jmedchem.7b01114
Abstract: The focused set of new pyrrolidine-2,5-diones as potential broad-spectrum hybrid anticonvulsants was described. These derivatives integrate on the common structural scaffold the chemical fragments of well-known antiepileptic drugs such as ethosuximide, levetiracetam, and lacosamide. Such… read more here.
Keywords: derived dioxopyrrolidin; hybrid compounds; seizure models; compounds derived ... See more keywords
Leishmanicidal phenolic compounds derived from Dalbergia cultrata.
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DOI: 10.1080/14786419.2020.1744140
Abstract: Leishmaniasis is a protozoan tropical infection that is estimated to be more than 0.3 million new cases occur annually worldwide. A novel phenolic compound, cultratin A (1), was isolated as a leishmanicidal constituent from the… read more here.
Keywords: derived dalbergia; leishmanicidal phenolic; dalbergia cultrata; compound ... See more keywords
Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone
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DOI: 10.1155/2021/5540173
Abstract: A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The… read more here.
Keywords: new triazole; microwave assisted; triazole compounds; derived acridone ... See more keywords
Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide.
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DOI: 10.2174/1570179417666200325124712
Abstract: Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide, because this… read more here.
Keywords: synthesis medicinal; advances synthesis; medicinal applications; applications compounds ... See more keywords
In Silico Studies on Compounds Derived from Calceolaria: Phenylethanoid Glycosides as Potential Multitarget Inhibitors for the Development of Pesticides
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DOI: 10.3390/biom8040121
Abstract: An increasing occurrence of resistance in insect pests and high mammal toxicity exhibited by common pesticides increase the need for new alternative molecules. Among these alternatives, bioinsecticides are considered to be environmentally friendly and safer… read more here.
Keywords: potential multitarget; silico studies; studies compounds; compounds derived ... See more keywords
Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
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DOI: 10.3390/md17120670
Abstract: Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as… read more here.
Keywords: natural compounds; compounds derived; bioactivities natural; natural products ... See more keywords
Anti-Inflammatory Activity of Compounds Derived from Vitex rotundifolia
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DOI: 10.3390/metabo13020249
Abstract: The objective of this study is to describe the separation and identification of one new phenolic and 19 known compounds from Vitex rotundifolia. Their structures were determined based on spectroscopic (NMR, CD, and MS) data… read more here.
Keywords: inhibition; vitex rotundifolia; activity compounds; compounds derived ... See more keywords