Modeling association detection in order to discover compounds to inhibit oral cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical informatics"
DOI: 10.1016/j.jbi.2018.07.005
Abstract: In the past, algorithms exploiting varying semantics in interactions between biological objects such as genes and diseases have been used in bioinformatics to uncover latent relationships within biological datasets. In this paper, we consider the… read more here.
Keywords: compounds inhibit; discover compounds; oral cancer; inhibit oral ... See more keywords
A drug discovery platform to identify compounds that inhibit EGFR triple mutants
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-0484-2
Abstract: Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug… read more here.
Keywords: compounds inhibit; drug; drug screening; platform ... See more keywords
Natural occurring compounds inhibit osteoclastogenesis via targeting on NFATc1-related signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug targets"
DOI: 10.2174/1389450120666191017121610
Abstract: Osteoclasts are originated from monocytic precursors of the hematopoietic lineage. Regulation of gene expression by transcription factors is one of the major mechanisms for controlling cellular functions. This is particularly important in the process of… read more here.
Keywords: occurring compounds; compounds inhibit; osteoclastogenesis via; natural occurring ... See more keywords
Polyphenolic Compounds Inhibit Osteoclast Differentiation While Reducing Autophagy through Limiting ROS and the Mitochondrial Membrane Potential
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091220
Abstract: Polyphenolic compounds are a diverse group of natural compounds that interact with various cellular proteins responsible for cell survival, differentiation, and apoptosis. However, it is yet to be established how these compounds interact in myeloid… read more here.
Keywords: osteoclast differentiation; compounds inhibit; inhibit osteoclast; mitochondrial membrane ... See more keywords