Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Research Reviews"
DOI: 10.1002/med.22014
Abstract: Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis, with anti‐inflammation, antioxidative stress, anticancer, and antifibrosis beneficial effects. AMPK is dysregulated in human… read more here.
Keywords: pulmonary diseases; synthetic compounds; evidence using; using synthetic ... See more keywords
Ligand fishing with cellular membrane-coated cellulose filter paper: a new method for screening of potential active compounds from natural products
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01662-z
Abstract: AbstractLigand fishing is a widely used approach for screening active compounds from natural products. Recently, cell membrane (CM) as affinity ligand has been applied in ligand fishing, including cell membrane chromatography (CMC) and CM-coated magnetic… read more here.
Keywords: natural products; ligand fishing; active compounds; filter paper ... See more keywords
Targeting bioactive compounds in natural extracts - Development of a comprehensive workflow combining chemical and biological data.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.04.038
Abstract: In natural product drug discovery, several strategies have emerged to highlight specifically bioactive compound(s) within complex mixtures (fractions or crude extracts) using metabolomics tools. In this area, a great deal of interest has raised among… read more here.
Keywords: compounds natural; biological data; natural extracts; targeting bioactive ... See more keywords
Comprehensive analysis of phenolic compounds from natural products: Integrating sample preparation and analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338845
Abstract: The comprehensive analysis of phenolic compounds from natural products comprises critical steps, including quantitative extraction, extract preparation, and chromatographic procedure. Performing these steps off-line requires a long time to obtain results, besides being laborious and… read more here.
Keywords: extraction; natural products; analysis; separation ... See more keywords
The Role of Bioactive Compounds in Natural Products Extracted from Plants in Cancer Treatment and Their Mechanisms Related to Anticancer Effects
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1429869
Abstract: Cancer is one of the greatest causes of death worldwide. With the development of surgery, radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved. However, the underlying mechanisms of cancer are not… read more here.
Keywords: cancer; compounds natural; bioactive compounds; treatment ... See more keywords
Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052672
Abstract: Receptors are macromolecules that transmit information regulating cell proliferation, differentiation, migration and apoptosis, play key roles in oncogenic processes and correlate with the prognoses of cancer patients. Thus, targeting receptors to constrain cancer development and… read more here.
Keywords: cancer; small molecule; compounds natural; development progression ... See more keywords
Endoplasmic Reticulum Stress in Gliomas: Exploiting a Dual-Effect Dysfunction through Chemical Pharmaceutical Compounds and Natural Derivatives for Therapeutical Uses
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25074078
Abstract: The endoplasmic reticulum maintains proteostasis, which can be disrupted by oxidative stress, nutrient deprivation, hypoxia, lack of ATP, and toxicity caused by xenobiotic compounds, all of which can result in the accumulation of misfolded proteins.… read more here.
Keywords: reticulum stress; stress; endoplasmic reticulum; compounds natural ... See more keywords
Special Issue—“Bioactive Compounds from Natural Sources II”
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28114450
Abstract: In recent decades, there has been a great interest in bioactive compounds from natural sources [...] read more here.
Keywords: issue bioactive; bioactive compounds; natural sources; compounds natural ... See more keywords
Antiviral Compounds from Natural Sources Against Human Arboviruses: An Updated Review Including Illustrative In Silico Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Pathogens"
DOI: 10.3390/pathogens14111156
Abstract: Arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) remain major global health threats, especially in tropical regions, with no effective antiviral treatments available. Recent research highlights progress in identifying antiviral compounds from natural… read more here.
Keywords: arboviruses updated; compounds natural; human arboviruses; natural sources ... See more keywords
Magnetic Molecularly Imprinted Polymers: An Update on Their Use in the Separation of Active Compounds from Natural Products
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14071389
Abstract: During the last few years, separation techniques using molecularly imprinted polymers (MIPs) have been developed, making breakthroughs using magnetic properties. Compared to conventional MIPs, magnetic molecularly imprinted polymers (MMIPs) have advantages in sample pretreatment due… read more here.
Keywords: imprinted polymers; molecularly imprinted; active compounds; natural products ... See more keywords