Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B.
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DOI: 10.1021/acsmedchemlett.2c00098
Abstract: We used mechanism-informed phenotypic screening to identify and optimize compounds that phenocopy the genetic depletion of the mitotic aurora kinase B (AURKB) kinase. After assaying nine aryl fused seven-membered lactam compounds, we identified a hit… read more here.
Keywords: membered lactam; aurora kinase; seven membered; lactam based ... See more keywords