Evaluation of algal active compounds as potent antibiofilm agent.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202100470
Abstract: Biofilm is the syntrophic association of microbial colonies that remain adhered to the biotic and abiotic surfaces with the help of self-secreted polymeric substances also termed extracellular polymeric substances. Chronic pathogenicity caused by biofilm-associated pathogenic… read more here.
Keywords: active compounds; evaluation algal; algal active; antibiofilm agent ... See more keywords
Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB1R) Receptor with Reduced Lipophilicity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01836
Abstract: In the present report, we describe the synthesis and structure-activity relationships of novel "four-arm" dihydropyrazoline compounds designed as peripherally restricted antagonists of cannabinoid-1 receptor (CB1R). A series of racemic 3,4-diarylpyrazolines were synthesized and evaluated initially… read more here.
Keywords: series; antagonists cannabinoid; cb1r; synthesis ... See more keywords
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00619
Abstract: Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand… read more here.
Keywords: broad spectrum; alkyl guanidine; compounds potent; guanidine compounds ... See more keywords