Diazabenzo[a]phenoxazone sulphonamides: synthesis, in-silico and in-vitro antimicrobial studies
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2251-4
Abstract: The syntheses of new sulphonamide derivatives of 8,10-diazabenzo[a]phenoxazones are reported. The condensation of 4,5-diamino-6-hydroxy-2-mercaptopyrimidine and 2,3-dichloro-1,4-naphthoquinone in a basic medium gave the key functional intermediate, 11-amino-6-chloro-9-mercapto-8,10-diazabenzo[a]phenoxazin-5-one. The conversion of the later compound to its sulphonamide… read more here.
Keywords: phenoxazone sulphonamides; synthesis silico; compounds showed; sulphonamides synthesis ... See more keywords
Design, synthesis, and antitumor evaluation of novel naphthalimide derivatives
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DOI: 10.1007/s00044-019-02471-w
Abstract: In order to research the structure–activity relationships of novel naphthalimide derivatives bearing disulfide bond toward antitumor activity, we prepared a series of those and their in vitro antiproliferative activities were screened against human cancer cell… read more here.
Keywords: naphthalimide derivatives; antitumor activity; compounds showed; novel naphthalimide ... See more keywords
Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis.
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DOI: 10.1016/j.bioorg.2022.105809
Abstract: Substituted aldehydes, ethyl 2-(2-amino-thiazol-4-yl)acetate), and 2-mercaptoacetic acid, in a three-component one-pot green synthetic approach afforded 2-arylthiazolidin-4-one- thiazole hybrids(T1-T13). Compounds showed good anti-tubercular activity towards sensitive M. tuberculosis strain. Compound T8 was as potent as isoniazide… read more here.
Keywords: activity; tuberculosis; thiazole hybrids; arylthiazolidin one ... See more keywords
Antiproliferative and cytotoxic secondary metabolites from fruits of Leplaea mayombensis
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DOI: 10.1080/14786419.2017.1402321
Abstract: Abstract Two new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3–12). Structures of the new compounds were elucidated by extensive… read more here.
Keywords: cytotoxic secondary; antiproliferative cytotoxic; compounds showed; leplaea mayombensis ... See more keywords
Virtual screening of zinc compounds similar to NSAIDS with better pharmacodynamic and pharmacokinetic profiles
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DOI: 10.12688/f1000research.132017.1
Abstract: BACKGROUND: Pain is a common symptom that is managed in both outpatients and inpatients. There are many side effects associated with opioids such as respiratory depression, constipation, hyperalgesia, and tolerance. Non- steroidal anti-inflammatory drugs cause… read more here.
Keywords: zinc compounds; zinc; screening zinc; virtual screening ... See more keywords