Azulene-based compounds for targeting orexin receptors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.040
Abstract: A library of 70 000 synthetically accessible azulene-based compounds was virtually screened at the OX2 receptor. Based on the results, a series of azulene derivatives was synthesized and the binding to and activation of both orexin… read more here.
Keywords: targeting orexin; orexin; orexin receptors; azulene based ... See more keywords
Phytochemical compounds targeting on Nrf2 for chemoprevention in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173588
Abstract: Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a… read more here.
Keywords: colorectal cancer; chemoprevention; targeting nrf2; cancer ... See more keywords
Identification of Compounds Targeting HuD: Another Brick in the Wall of Neurodegenerative Disease Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00191
Abstract: ELAV-like (ELAVL) RNA-binding proteins play a pivotal role in post-transcriptional processes, and their dysregulation is involved in several pathologies. This work was focused on HuD (ELAVL4), which is specifically expressed in nervous tissues, and involved… read more here.
Keywords: hud; identification compounds; treatment; targeting hud ... See more keywords
Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00188
Abstract: Important steps in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserved signal transduction cascade. However, Hh activity not only is crucial during embryo formation but also is involved in adult… read more here.
Keywords: update pharmacological; hedgehog update; inhibiting hedgehog; targeting strategies ... See more keywords
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry
Sign Up to like & getrecommendations! Published in 2021 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00619
Abstract: Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 is a reported entry point for several viruses, including severe acute… read more here.
Keywords: virus entry; sars cov; cov virus; entry ... See more keywords
A Microenvironment Screen Identifies Compounds Targeting pre-LSCs.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2016-212
Abstract: 2-ME2 selectively targets pre-LSCs by inhibiting MYC translation and SCL activity. read more here.
Keywords: screen identifies; identifies compounds; microenvironment screen; compounds targeting ... See more keywords
Therapeutic compounds targeting Lipid II for antibacterial purposes
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s215070
Abstract: Abstract Resistance against commonly used antibiotics has emerged in all bacterial pathogens. In fact, there is no antibiotic currently in clinical use against which resistance has not been reported. In particular, rapidly increasing urbanization in… read more here.
Keywords: targeting lipid; resistance; therapeutic compounds; cell wall ... See more keywords
Therapeutic potential of compounds targeting SARS-CoV-2 helicase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1062352
Abstract: The economical and societal impact of COVID-19 has made the development of vaccines and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein has been widely explored as a drug target, the… read more here.
Keywords: therapeutic potential; compounds targeting; cov helicase; helicase ... See more keywords
Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082568
Abstract: Cancer is a complex pathology that causes a large number of deaths worldwide. Several risk factors are involved in tumor transformation, including epigenetic factors. These factors are a set of changes that do not affect… read more here.
Keywords: histone deacetylases; natural bioactive; compounds targeting; bioactive compounds ... See more keywords