Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adj4452
Abstract: Most genetic variants associated with psychiatric disorders are located in noncoding regions of the genome. To investigate their functional implications, we integrate epigenetic data from the PsychENCODE Consortium and other published sources to construct a… read more here.
Keywords: regulatory elements; brain; using comprehensive; comprehensive atlas ... See more keywords
ICASA: An Interactive Comprehensive Atlas of Single Cells in AML from 82 Bone Marrow Samples
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202595
Abstract: Background: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by arrested differentiation and clonal expansion. While certain efforts have been devoted to integrating single-cell data in AML, there is a clear need to build… read more here.
Keywords: interactive comprehensive; analysis; atlas single; cell ... See more keywords
A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.867015
Abstract: Animal models are an integral part of the drug development and evaluation process. However, they are unsurprisingly imperfect reflections of humans, and the extent and nature of many immunological differences are unknown. With the rise… read more here.
Keywords: immunological differences; cell; atlas immunological; comprehensive atlas ... See more keywords
Comprehensive Atlas of Circulating Rare Cells Detected by SE-iFISH and Image Scanning Platform in Patients With Various Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.821454
Abstract: Objective Circulating rare cells (CRCs) are known as a crucial nucleated cellular response to pathological conditions, yet the landscape of cell types across a wide variety of diseases lacks comprehensive understanding. This study aimed at… read more here.
Keywords: image scanning; comprehensive atlas; circulating rare; crcs ... See more keywords