Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.02.036
Abstract: Summary Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which… read more here.
Keywords: analysis reveals; comprehensive genomic; foxa1 binding; foxa1 ... See more keywords
Diverse EGFR Exon 20 Insertions and Co‐Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.06.019
Abstract: Introduction: EGFR exon 20 insertions (EGFRex20ins) comprise an uncommon subset of EGFR‐activating alterations relatively insensitive to first‐ and second‐generation EGFR tyrosine kinase inhibitors (TKIs). However, recent early clinical data suggests these patients may benefit from… read more here.
Keywords: generation egfr; egfr; comprehensive genomic; egfr exon ... See more keywords
Challenges of Conducting Value Assessment for Comprehensive Genomic Profiling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s026646232200040x
Abstract: Abstract Objectives Clinical practice is shifting toward an era of precision medicine. The use of comprehensive genomic profiling (CGP) in oncology has broad potential as a universal companion diagnostic for targeted therapies which may significantly… read more here.
Keywords: oncology; cgp; value assessment; assessment ... See more keywords
Comprehensive genomic profiling of Brazilian non‐small cell lung cancer patients (GBOT 0118/LACOG0418)
Sign Up to like & getrecommendations! Published in 2020 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13777
Abstract: The aim of this study was to carry out a descriptive analysis of the somatic genetic profile and co‐occurring mutations of non‐small cell lung cancer (NSCLC) samples from patients tested with comprehensive genomic profiling (CGP). read more here.
Keywords: non small; comprehensive genomic; cell lung; lung cancer ... See more keywords
Clinical application of comprehensive genomic profiling panel to thoracic malignancies: A single‐center retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14643
Abstract: The usefulness of comprehensive genomic profiling (CGP) panels for thoracic malignancies after completion of the standard treatment is unclear. read more here.
Keywords: thoracic malignancies; genomic profiling; clinical application; application comprehensive ... See more keywords
Comprehensive genomic diagnosis of inherited retinal and optical nerve disorders reveals hidden syndromes and personalized therapeutic options
Sign Up to like & getrecommendations! Published in 2020 at "Acta Ophthalmologica"
DOI: 10.1111/aos.14479
Abstract: In the era of precision medicine, genomic characterization of blind patients is critical. Here, we evaluate the effects of comprehensive genetic analysis on the etiologic diagnosis of potentially hereditary vision loss and its impact on… read more here.
Keywords: diagnosis inherited; genomic diagnosis; comprehensive genomic; diagnosis ... See more keywords
Feasibility and clinical utility of comprehensive genomic profiling of hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15427
Abstract: Identification of genetic alterations through next‐generation sequencing (NGS) can guide treatment decision‐making by providing information on diagnosis, therapy selection, and prognostic stratification in patients with hematological malignancies. Although the utility of NGS‐based genomic profiling assays… read more here.
Keywords: genomic profiling; feasibility clinical; comprehensive genomic; clinical utility ... See more keywords
Expert panel consensus recommendations on the use of circulating tumor DNA assays for patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15504
Abstract: Comprehensive genomic profiling is increasingly used to facilitate precision oncology based on molecular stratification. In addition to conventional tissue comprehensive genomic profiling, comprehensive genomic profiling of circulating tumor DNA has become widely utilized in cancer… read more here.
Keywords: circulating tumor; genomic profiling; tumor; comprehensive genomic ... See more keywords
Prognostic benefit of comprehensive genomic profiling in clinical practice remains uncertain.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15826
Abstract: The overall survival of patients who received genomically matched therapy was not significantly longer than that of patients receiving treatment only other than genomically matched therapy in the breast invasive ductal carcinoma (A), colorectal adenocarcinoma… read more here.
Keywords: profiling clinical; genomic profiling; benefit comprehensive; prognostic benefit ... See more keywords
Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-1804
Abstract: Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular characteristics are still undefined. We explored the underlying biology of GEP-NENs and the differences between gastrointestinal (GI) and pancreatic (PNEN), high-grade (HG), and low-grade (LG)… read more here.
Keywords: genomic profiling; gep nens; biology; profiling gastroenteropancreatic ... See more keywords
Abstract 232: Fully automated comprehensive genomic profiling for detection of cancer variants, gene fusions, and complex oncology endpoints
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-232
Abstract: Introduction: We present the comprehensive genomic profiling performance of the Ion Torrent Genexus system using the Oncomine Comprehensive Assay Plus (OCA Plus), a 500+ gene targeted AmpliSeq-based oncology research panel that evaluates DNA variants (including… read more here.
Keywords: oncology; genomic profiling; comprehensive genomic; detection ... See more keywords