A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118688119
Abstract: Significance The ability to extract multigenerational family relationships from large-scale population cohorts provides a powerful means to understand the heritability of a wide range of diseases and their genetic relationships to each other. By showing… read more here.
Keywords: comprehensive map; heritability; genealogy; genetic relationships ... See more keywords
A comprehensive map of hotspots of de novo telomere addition in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad076
Abstract: Telomere healing occurs when telomerase, normally restricted to chromosome ends, acts upon a double-strand break to create a new, functional telomere. De novo telomere addition on the centromere-proximal side of a break truncates the chromosome… read more here.
Keywords: hotspots novo; addition; comprehensive map; telomere addition ... See more keywords
A comprehensive map of microbial biomarkers along the gastrointestinal tract for celiac disease patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.956119
Abstract: Dysbiosis of the microbiome has been related to Celiac disease (CeD) progress, an autoimmune disease characterized by gluten intolerance developed in genetically susceptible individuals under certain environmental factors. The microbiome contributes to CeD pathophysiology, modulating… read more here.
Keywords: comprehensive map; celiac disease; disease; map microbial ... See more keywords
A comprehensive map of preferentially located motifs reveals distinct proximal cis-regulatory sequences in plants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.976371
Abstract: The identification of cis-regulatory elements controlling gene expression is an arduous challenge that is being actively explored to discover the key genetic factors responsible for traits of agronomic interest. Here, we have used a de… read more here.
Keywords: comprehensive map; proximal cis; cis regulatory; cis ... See more keywords