Comprehensive in vivo and in silico approaches to explore the hepatoprotective activity of poncirin against paracetamol toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-021-02192-1
Abstract: In the present study, poncirin was evaluated against paracetamol-induced liver injury using in vivo and computational approaches. Paracetamol was administered intraperitoneally (i.p,) to establish liver injury in mice and, subsequently, to investigate the hepatoprotective effect… read more here.
Keywords: paracetamol; poncirin; liver injury; activity ... See more keywords
A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.02.010
Abstract: microRNAs (miRNAs) are ∼21-22 nucleotide (nt) RNAs that mediate broad post-transcriptional regulatory networks. However, genetic analyses have shown that the phenotypic consequences of deleting individual miRNAs are generally far less overt compared to their misexpression.… read more here.
Keywords: apoptotic mirnas; anti apoptotic; screen anti; comprehensive vivo ... See more keywords