The computation of biomarkers in pharmacokinetics with the aid of singular perturbation methods
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DOI: 10.1007/s00285-018-1257-3
Abstract: In pharmacokinetics, exact solutions to one-compartment models with nonlinear elimination kinetics cannot be found analytically, if dosages are assumed to be administered repetitively through extravascular routes (Tang and Xiao in J Pharmacokinet Pharmacodyn 34(6):807–827, 2007).… read more here.
Keywords: computation biomarkers; perturbation methods; singular perturbation; biomarkers pharmacokinetics ... See more keywords