Emerging Computational Methods in Mass Spectrometry Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203339
Abstract: Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of hundreds of molecules in biological samples with high sensitivity and molecular specificity. Advanced MSI platforms with capability of high‐spatial resolution and high‐throughput… read more here.
Keywords: mass spectrometry; computational methods; emerging computational; spectrometry imaging ... See more keywords
Insight workflow: Systematically combining human and computational methods to explore textual data
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Association for Information Science and Technology"
DOI: 10.1002/asi.23767
Abstract: Analyzing large quantities of real‐world textual data has the potential to provide new insights for researchers. However, such data present challenges for both human and computational methods, requiring a diverse range of specialist skills, often… read more here.
Keywords: human computational; workflow systematically; analysis; computational methods ... See more keywords
Computational methods and translational applications for targeted next‐generation sequencing platforms
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23023
Abstract: During the past decade, next‐generation sequencing (NGS) technologies have become widely adopted in cancer research and clinical care. Common applications within the clinical setting include patient stratification into relevant molecular subtypes, identification of biomarkers of… read more here.
Keywords: methods translational; computational methods; next generation; translational applications ... See more keywords
How computational methods and relativistic effects influence the study of chemical reactions involving Ru‐NO complexes?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.24762
Abstract: Two treatments of relativistic effects, namely effective core potentials (ECP) and all‐electron scalar relativistic effects (DKH2), are used to obtain geometries and chemical reaction energies for a series of ruthenium complexes in B3LYP/def2‐TZVP calculations. Specifically,… read more here.
Keywords: influence study; relativistic effects; effects influence; computational methods ... See more keywords
Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13C MR EPSI studies of liver tumors
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28901
Abstract: To develop a novel post‐processing pipeline for hyperpolarized (HP) 13C MRSI that integrates tensor denoising and B1+ correction to measure pyruvate‐to‐lactate conversion rates (kPL) in patients with liver tumors. read more here.
Keywords: specialized computational; liver tumors; denoising correction; hyperpolarized 13c ... See more keywords
Computational methods for predicting hotspots at protein–RNA interfaces
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1675
Abstract: Protein–RNA interactions play essential roles in many critical biological events. A comprehensive understanding of the mechanisms underlying these interactions is helpful when studying cellular activities and therapeutic applications. Hotspots are a small portion of residues… read more here.
Keywords: computational methods; predicting hotspots; hotspots protein; rna interactions ... See more keywords
Computational Methods for the Elucidation of Protein Structure and Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1406-8_2
Abstract: Biologists are increasingly aware of the importance of protein structure in revealing function. The computational tools now exist which allow researchers to model unknown proteins simply on the basis of their primary sequence. However, for… read more here.
Keywords: methods elucidation; elucidation protein; protein structure; computational methods ... See more keywords
Computational Methods for Pseudogene Annotation Based on Sequence Homology.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1503-4_3
Abstract: The number of complete genome sequences explodes more and more with each passing year. Thus, methods for genome annotation need to be honed constantly to handle the deluge of information. Annotation of pseudogenes (i.e., gene… read more here.
Keywords: annotation; sequence homology; computational methods; pseudogene annotation ... See more keywords
Computational Methods for Analysis of Tumor Clonality and Evolutionary History.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8868-6_13
Abstract: Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct… read more here.
Keywords: clonality evolutionary; tumor clonality; methods analysis; computational methods ... See more keywords
Computational Methods for Drug Repurposing
Sign Up to like & getrecommendations! Published in 2019 at "Methods in Molecular Biology"
DOI: 10.1007/978-1-4939-8955-3
Abstract: Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have… read more here.
Keywords: protein; drug repurposing; methods drug; drug ... See more keywords
Fluctuating hydrodynamic methods for fluid-structure interactions in confined channel geometries
Sign Up to like & getrecommendations! Published in 2017 at "Applied Mathematics and Mechanics"
DOI: 10.1007/s10483-018-2253-8
Abstract: We develop computational methods for the study of fluid-structure interactions subject to thermal fluctuations when confined within channels with slit-like geometry. The methods take into account the hydrodynamic coupling and diffusivity of microstructures when influenced… read more here.
Keywords: fluctuating hydrodynamic; structure interactions; computational methods; fluid structure ... See more keywords