Machines on Genes through the Computational Microscope.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c01313
Abstract: Macromolecular machines acting on genes are at the core of life's fundamental processes, including DNA replication and repair, gene transcription and regulation, chromatin packaging, RNA splicing, and genome editing. Here, we report the increasing role… read more here.
Keywords: biophysics; computational microscope; machines genes; genes computational ... See more keywords
An omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1340272
Abstract: ABSTRACT Introduction: Metallo-drugs have attracted enormous interest for cancer treatment. The achievements of this drug-type are summarized by the success story of cisplatin. That being said, there have been many drawbacks with its clinical use,… read more here.
Keywords: perspective molecular; omics perspective; computational microscope; molecular mechanisms ... See more keywords