Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74591-y
Abstract: Applications of machine learning and graph theory techniques to neuroscience have witnessed an increased interest in the last decade due to the large data availability and unprecedented technology developments. Their employment to investigate the effect… read more here.
Keywords: pipeline; nav1 gain; probe nav1; computational pipeline ... See more keywords
A computational pipeline for functional gene discovery
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03041-0
Abstract: Many computational pipelines exist for the detection of differentially expressed genes. However, computational pipelines for functional gene detection rarely exist. We developed a new computational pipeline for functional gene identification from transcriptome profiling data. Key… read more here.
Keywords: pipeline functional; gene discovery; computational pipeline; pipeline ... See more keywords
An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab338
Abstract: Protein engineering and design principles employing the 20 standard amino acids have been extensively used to achieve stable protein scaffolds and deliver their specific activities. Although this confers some advantages, it often restricts the sequence,… read more here.
Keywords: affinity; nanobody; computational pipeline; integrated computational ... See more keywords
A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz094
Abstract: Abstract Hypoxia is associated with several diseases, including cancer. Cells that are deprived of adequate oxygen supply trigger transcriptional and post-transcriptional responses, which control cellular pathways such as angiogenesis, proliferation, and metabolic adaptation. Circular RNAs… read more here.
Keywords: circular rnas; human cancer; computational pipeline; hypoxic stress ... See more keywords
Assessing a computational pipeline to identify binding motifs to the α2β1 integrin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1107400
Abstract: Integrins in the cell surface interact with functional motifs found in the extracellular matrix (ECM) that queue the cell for biological actions such as migration, adhesion, or growth. Multiple fibrous proteins such as collagen or… read more here.
Keywords: computational pipeline; pipeline identify; binding motifs; motifs integrin ... See more keywords
Computational Pipeline for Glomerular Segmentation and Association of the Quantified Regions with Prognosis of Kidney Function in IgA Nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12122955
Abstract: The histopathological findings of the glomeruli from whole slide images (WSIs) of a renal biopsy play an important role in diagnosing and grading kidney disease. This study aimed to develop an automated computational pipeline to… read more here.
Keywords: computational pipeline; kidney; kidney function; prognosis kidney ... See more keywords