Computational Structural Biology of S-nitrosylation of Cancer Targets
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DOI: 10.3389/fonc.2018.00272
Abstract: Nitric oxide (NO) plays an essential role in redox signaling in normal and pathological cellular conditions. In particular, it is well known to react in vivo with cysteines by the so-called S-nitrosylation reaction. S-nitrosylation is… read more here.
Keywords: computational structural; structural biology; nitrosylation; biology ... See more keywords
Pharmacological Chaperones and Protein Conformational Diseases: Approaches of Computational Structural Biology
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DOI: 10.3390/ijms24065819
Abstract: Whenever a protein fails to fold into its native structure, a profound detrimental effect is likely to occur, and a disease is often developed. Protein conformational disorders arise when proteins adopt abnormal conformations due to… read more here.
Keywords: conformational diseases; structural biology; pharmacological chaperones; computational structural ... See more keywords
Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors
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DOI: 10.3390/molecules27082479
Abstract: The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases. Deciphering the structural properties of kainate receptor ligands is crucial… read more here.
Keywords: structural studies; experimental computational; computational structural; competitive antagonists ... See more keywords