Computationally Guided Intracerebral Drug Delivery via Chronically Implanted Microdevices.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107734
Abstract: Treatments for neurologic diseases are often limited in efficacy due to poor spatial and temporal control over their delivery. Intracerebral delivery partially overcomes this by directly infusing therapeutics to the brain. Brain structures, however, are… read more here.
Keywords: computationally guided; drug delivery; delivery; coverage ... See more keywords
Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00033
Abstract: Enhancing the thermostability of enzymes without impacting their catalytic function represents an important yet challenging goal in protein engineering and biocatalysis. We recently introduced a novel method for enzyme thermostabilization that relies on the computationally… read more here.
Keywords: stabilization; covalent stapling; structural basis; thermostability ... See more keywords
Computationally Guided Discovery of Axis-Dependent Conduction Polarity in NaSnAs Crystals
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.0c04030
Abstract: Most electronic materials exhibit a single dominant charge carrier type, either holes or electrons, along all crystallographic directions. However, there are a small number of compounds, mostly met... read more here.
Keywords: computationally guided; dependent conduction; conduction polarity; discovery axis ... See more keywords