Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2022.2086303
Abstract: Abstract Objective Thermosensitive liposomes (TSL) and other triggered drug delivery systems (DDS) are promising therapeutic strategies for targeted drug delivery. However, successful designs with candidate drugs depend on many variables, including nanoparticle formulation, drug properties,… read more here.
Keywords: cell; thermosensitive liposomes; cell uptake; computer model ... See more keywords
Development of a multiscale electromechanical computer model from cell to hemodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Europace"
DOI: 10.1093/europace/euab116.509
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): CVON eDETECT 2015-12 Patients with genetic cardiomyopathies mostly remain asymptomatic until the occurrence of life-threatening arrhythmias and sudden cardiac death. The responsible… read more here.
Keywords: hemodynamics; multiscale electromechanical; electromechanical computer; computer model ... See more keywords
Computer model of IL-6 dependent rheumatoid arthritis in F759 mice.
Sign Up to like & getrecommendations! Published in 2023 at "International immunology"
DOI: 10.1093/intimm/dxad016
Abstract: The IL-6 amplifier, which describes the simultaneous activation of STAT3 and NF-kB, in synovial fibroblasts causes the infiltration of immune cells into the joints of F759 mice. The result is a disease that resembles human… read more here.
Keywords: rheumatoid arthritis; stat3; arthritis; computer model ... See more keywords
Prediction of patient disposition: comparison of computer and human approaches and a proposed synthesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Medical Informatics Association : JAMIA"
DOI: 10.1093/jamia/ocab076
Abstract: OBJECTIVE To compare the accuracy of computer versus physician predictions of hospitalization and to explore the potential synergies of hybrid physician-computer models. MATERIALS AND METHODS A single-center prospective observational study in a tertiary pediatric hospital… read more here.
Keywords: patient disposition; model; computer; computer model ... See more keywords
Malignancy risk estimation of pulmonary nodules in screening CTs: Comparison between a computer model and human observers
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185032
Abstract: Purpose To compare human observers to a mathematically derived computer model for differentiation between malignant and benign pulmonary nodules detected on baseline screening computed tomography (CT) scans. Methods A case-cohort study design was chosen. The… read more here.
Keywords: human observers; risk; computer; benign nodules ... See more keywords
A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0221425
Abstract: Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding normal and abnormal… read more here.
Keywords: artery; model; computer; arterial circulation ... See more keywords
The relationship between the vertical distribution of spiny lobster phyllosoma larvae (Crustacea: Palinuridae) and isolume depths generated by a computer model
Sign Up to like & getrecommendations! Published in 2017 at "Revista De Biologia Tropical"
DOI: 10.15517/rbt.v41i1.29294
Abstract: Diel vertical migration (DVM) of spiny lobster (Panulirus spp.) phyllosoma larvae may be a key component in the biological-physical coupling which affects their transport and survival in the Florida Keys. Light is often invoked as… read more here.
Keywords: spiny lobster; vertical distribution; computer model; distribution ... See more keywords
Verification of the Façade Scaffolding Computer Model
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Civil Engineering"
DOI: 10.2478/ace-2018-0003
Abstract: Abstract This paper presents an analysis of natural vibrations of typical façade scaffolding. Three Finite Element Method models with different levels of accuracy of the real structure of the scaffolding representation were used. Modal analysis… read more here.
Keywords: verification ade; computer model; ade scaffolding; scaffolding computer ... See more keywords
Stochastic Computer Model of the Kinetics of Multicomponent Intercrystalline Adsorption in Solid Solutions
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of the Russian Academy of Sciences: Physics"
DOI: 10.3103/s1062873818090083
Abstract: The basic principles of constructing a stochastic computer model of intergranular adsorption kinetics controlled by interatomic pair interactions and the volume diffusion mobility of the components of a solid solution are developed, allowing for the… read more here.
Keywords: adsorption; model kinetics; stochastic computer; computer ... See more keywords
Evaluation of a 3D Computer Model of the Equine Paranasal Sinuses as a Tool for Veterinary Anatomy Education.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of veterinary medical education"
DOI: 10.3138/jvme-2021-0134
Abstract: Detailed knowledge of anatomical systems is vital for clinical veterinary practice. However, students often find it difficult to transfer skills learned from textbooks to real-life practice. In this study, a three-dimensional computer model representing equine… read more here.
Keywords: group; computer model; anatomy; model ... See more keywords
Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1099470
Abstract: Objectives Graves' disease (GD) with onset in childhood or adolescence is a rare disease (ORPHA:525731). Current pharmacotherapeutic approaches use antithyroid drugs, such as carbimazole, as monotherapy or in combination with thyroxine hormone substitutes, such as… read more here.
Keywords: pharmacometrics computer; disease; clinically practical; computer model ... See more keywords