New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies
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DOI: 10.1038/s41598-017-10618-1
Abstract: Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be… read more here.
Keywords: synthase inhibitors; comsia; trna synthase; tyrosyl trna ... See more keywords
Structural Insights on Hyp-Gly-Containing Peptides as Antiplatelet Compounds through Topomer CoMFA and CoMSIA Analysis
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DOI: 10.3390/foods12040777
Abstract: Increasing evidence has shown collagen hydrolysate involves a variety of bioactivities. In our previous study, multiple antiplatelet peptides containing Hyp/Pro-Gly were identified in collagen hydrolysates from Salmo salar and silver carp skin and exhibited anti-thrombosis… read more here.
Keywords: topomer comfa; activity; value; containing peptides ... See more keywords
3D-QSAR Studies of Isatin Derivatives with Anti-Cancer In Vitro: AdvancedCoMFA, CoMSIA and Docking Methods
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DOI: 10.4172/2150-3494.1000158
Abstract: Three-dimensional quantitative structure–activity relationship (3D-QSAR) and docking methods were performed to study 47 tubulin inhibitors, isatin derivatives with anticancer activity against human monocyte-like histiocytic lymphoma human U937 cells. The established 3D-QSAR model from Comparative Molecular… read more here.
Keywords: derivatives anti; comsia; docking methods; studies isatin ... See more keywords