Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.850
Abstract: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. read more here.
Keywords: cannabis; onset psychosis; comt; age onset ... See more keywords
Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4940-6
Abstract: RationaleDepressed patients often present increased consumption of caffeine.ObjectivesWe aimed to investigate the effects of chronic treatment with caffeine (5 mg/kg, twice daily for 14 days) on the activity of single, ineffective doses of agomelatine (20 mg/kg) or mianserin… read more here.
Keywords: administration; caffeine; comt; day ... See more keywords
COMT genotype is associated with plasticity in sense of body ownership: a pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Psychological Research"
DOI: 10.1007/s00426-017-0849-7
Abstract: The sense of body ownership constantly adapts to new environments, and awareness of a distinction between oneself and others is a fundamental ability. However, it remains unclear whether plasticity in the sense of body ownership… read more here.
Keywords: body ownership; comt; ownership; sense body ... See more keywords
Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00495-0
Abstract: Obsessive–compulsive disorder (OCD) is a common psychiatric disorder that affects approximately 1–3% of the general population. It is characterized by disabling obsessions (intrusive unwanted thoughts) and/or compulsions (ritualized repetitive behaviors). Catechol-O-methyltransferase (COMT) enzyme has an… read more here.
Keywords: analysis; comt; val158met polymorphism; meta analysis ... See more keywords
Chronic persistent surgical pain is strongly associated with COMT alleles in patients undergoing cardiac surgery with median sternotomy
Sign Up to like & getrecommendations! Published in 2020 at "General Thoracic and Cardiovascular Surgery"
DOI: 10.1007/s11748-020-01321-6
Abstract: Objectives Catechol- O -methyl transferase (COMT), a catechol-dependent enzyme, plays pivotal role in the development of pain. In different ethnic populations, it is associated with chronic persistent surgical pain (CPSP). In this context, the present… read more here.
Keywords: surgery; chronic persistent; persistent surgical; cpsp ... See more keywords
Genetic Variation of COMT Impacts Mindfulness and Self-Reported Everyday Cognitive Failures but Not Self-Rated Attentional Control
Sign Up to like & getrecommendations! Published in 2018 at "Mindfulness"
DOI: 10.1007/s12671-018-0893-4
Abstract: The present study aimed to investigate potential associations between mindfulness and two prominent “cognitive” personality questionnaires (attentional control scale (ACS) and the cognitive failures questionnaire (CFQ)). Moreover, all participants (N = 537, n = 384 females; mean age =… read more here.
Keywords: attentional control; comt; everyday cognitive; cognitive failures ... See more keywords
Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: A study review
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.11.002
Abstract: The influence of individual differences in cognition and behavior may be partly explained by the different genetic polymorphisms. Among the genetic polymorphisms capable of altering cognitive and behavioral functions, the catechol-O-methyltransferase (COMT) Val158Met polymorphism regulates… read more here.
Keywords: motor behavior; comt; polymorphism motor; motor ... See more keywords
Influence of ADRB1, ADRB2, and COMT Genetic Polymorphisms on Postoperative Outcomes of Patients Undergoing Cardiac Valve Surgery.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2020.12.010
Abstract: PURPOSE The aim of this study is to prospectively investigate the influence of ADRB and COMT gene polymorphisms on postoperative outcomes of patients undergoing cardiac surgery. METHODS This prospective cohort study included 223 patients undergoing… read more here.
Keywords: undergoing cardiac; surgery; patients undergoing; comt ... See more keywords
Pharmacodynamic evaluation of novel Catechol‐O‐methyltransferase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.027
Abstract: ABSTRACT Currently, peripheral COMT inhibitors have an important role in the treatment of Parkinson's disease, and central COMT inhibitors have a potential role in the treatment of various neuropsychiatric disorders, such as attention deficit hyperactivity… read more here.
Keywords: evaluation novel; comt inhibitors; comt; pharmacodynamic evaluation ... See more keywords
Nonlinear modulation of interacting between COMT and depression on brain function
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.05.024
Abstract: Abstract Background: The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in… read more here.
Keywords: brain; comt; nonlinear modulation; brain function ... See more keywords
A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.12.088
Abstract: BACKGROUND COMT rs4680 Val158 allele is associated with high MB-COMT protein expression and elevated activity compared to the Met158 allele in post-mortem brains. A meta-analysis study suggested the link between COMT SNPs and MDD risk;… read more here.
Keywords: protein; mdd; haplotype; comt ... See more keywords