Identification of novel flavonoid inhibitor of Catechol-O-Methyltransferase enzyme by molecular screening, quantum mechanics/molecular mechanics and molecular dynamics simulations
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DOI: 10.1080/07391102.2019.1699446
Abstract: Abstract The low level of dopamine at substantia nigra (mid-brain) has been considered to be one of the reasons for Parkinson’s disease (PD). This dopamine deficit is due to the influence of Catechol-O-Methyltransferase (COMT). A… read more here.
Keywords: molecular screening; comt enzyme; molecular dynamics; mechanics molecular ... See more keywords