Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone.
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DOI: 10.1016/j.drudis.2020.07.015
Abstract: Catechol O-methyltransferase (COMT) inhibitors are valuable co-adjuvant drugs in the clinical management of Parkinson's disease (PD), and recent data also suggest therapeutic benefits in other neurological disorders associated with dopamine depletion. However, the relationship between… read more here.
Keywords: catechol methyltransferase; replace tolcapone; comt inhibitors; inhibitors replace ... See more keywords
Pharmacodynamic evaluation of novel Catechol‐O‐methyltransferase inhibitors
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DOI: 10.1016/j.ejphar.2019.01.027
Abstract: ABSTRACT Currently, peripheral COMT inhibitors have an important role in the treatment of Parkinson's disease, and central COMT inhibitors have a potential role in the treatment of various neuropsychiatric disorders, such as attention deficit hyperactivity… read more here.
Keywords: evaluation novel; comt inhibitors; comt; pharmacodynamic evaluation ... See more keywords