Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-62240-7
Abstract: To investigate the association between three selected pain polymorphisms and clinical, functional, sensory-related, psychophysical, psychological or cognitive variables in a sample of women with fibromyalgia (FMS). One hundred twenty-three (n = 123) women with FMS completed demographic… read more here.
Keywords: htr1b rs6296; comt rs4680; oprm1 rs1799971;
OPRM1 rs1799971 - COMT rs4680 - FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001578
Abstract: Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this… read more here.
Keywords: comt; rs324420 genes; oprm1 rs1799971; faah rs324420 ... See more keywords
Association Between COMT rs4680 (Val158Met) Polymorphism and Academic Performance among Medical Students.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2025.08.987
Abstract: OBJECTIVE To examine the association between the catechol-O-methyltransferase (COMT) rs4680 polymorphism - a common genetic variation in the gene, which regulates dopamine metabolism in the prefrontal cortex - and academic performance among medical students at a public-sector medical… read more here.
Keywords: polymorphism; academic performance; performance; comt rs4680 ... See more keywords
Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (OPRM1) rs1799971 and Catechol-O-Methyltransferase (COMT) rs4680, with Phenotypic Expression of Fibromyalgia
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13051183
Abstract: Background/Objectives: Genetic variants, such as the µ-opioid receptor 1 (OPRM1) rs1799971 and the catechol-O-methyltransferase (COMT) rs4680, have been considered among the potential causes in the development of some chronic pain conditions. In this regard, there… read more here.
Keywords: comt rs4680; comt; genetic variants; oprm1 rs1799971 ... See more keywords
Associations between the COMT rs4680 Gene Polymorphism and Personality Dimensions and Anxiety in Patients with a Diagnosis of Other Stimulants Dependence
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101768
Abstract: Background: Research on the hypodopaminergic hypothesis of addictions showed that hypodopaminergic activity in males predicted the number of drugs used and is associated with drug-seeking behavior. Variant alleles may cause hypodopaminergic functioning as a result… read more here.
Keywords: personality dimensions; polymorphism; control; comt rs4680 ... See more keywords
Influence of COMT (rs4680) and DRD2 (rs1076560, rs1800497) Gene Polymorphisms on Safety and Efficacy of Methylphenidate Treatment in Children with Fetal Alcohol Spectrum Disorders
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19084479
Abstract: Fetal alcohol spectrum disorders (FASD) in a course of high prenatal alcohol exposure (hPAE) are among the most common causes of developmental disorders. The main reason for pharmacological treatment of FASD children is attention deficit… read more here.
Keywords: comt rs4680; drd2 rs1076560; gene polymorphisms; treatment ... See more keywords
Dopaminergic Genetic Variation and Trait Impulsivity: The Role of COMT rs4680 in Mixed Behavioral and Substance Addictions
Sign Up to like & getrecommendations! Published in 2025 at "Life"
DOI: 10.3390/life15121836
Abstract: Background: Impulsivity is a multidimensional trait associated with the development and maintenance of behavioral and substance addictions. Genetic polymorphisms, particularly within the dopaminergic system, are thought to modulate individual differences in impulsivity. The COMT rs4680… read more here.
Keywords: behavioral substance; comt rs4680; substance addictions; impulsivity ... See more keywords