Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106071
Abstract: Nicotine, a potent parasympathomimetic alkaloid, manifests anti-inflammatory properties by activating nicotinic acetylcholine receptors (nAChRs). In this study, we evaluated the effects of nicotine on concanavalin A (ConA)-induced autoimmune hepatitis. Nicotine (0.5 and 1 mg/kg) was intraperitoneally… read more here.
Keywords: cona induced; kupffer cells; nicotinic acetylcholine; mice ... See more keywords
Interleukin-39 exacerbates concanavalin A-induced liver injury
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2020.1869778
Abstract: Abstract Background Interleukin (IL)-39 is a novel member of IL-12 family and has been reported to play a pro-inflammatory role in lupus-like mice, but its function in concanavalin A (ConA)-induced liver injury is currently unclear.… read more here.
Keywords: induced liver; interleukin; cona induced; liver injury ... See more keywords
NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00758
Abstract: Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropic proinflammatory cytokine and well known to be critical in… read more here.
Keywords: cona induced; hepatitis; inflammasome dependent; cona ... See more keywords
CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1041671
Abstract: Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in arthritis. However, the effects… read more here.
Keywords: inflammation; exerts protective; hepatitis; induced hepatitis ... See more keywords
Stem cells from human exfoliated deciduous teeth ameliorate concanavalin A-induced autoimmune hepatitis by protecting hepatocytes from apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Stem Cells"
DOI: 10.4252/wjsc.v12.i12.1623
Abstract: BACKGROUND Autoimmune hepatitis is a serious autoimmune liver disease that threatens human health worldwide, which emphasizes the urgent need to identify novel treatments. Stem cells from human exfoliated deciduous teeth (SHED), which are easy to… read more here.
Keywords: cona induced; hepatitis; cells human; autoimmune hepatitis ... See more keywords