3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-5267-1
Abstract: Background and AimsConcanavalin A is known to activate T cells and to cause liver injury and hepatitis, mediated in part by secretion of TNFα from macrophages. Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been shown to prevent… read more here.
Keywords: concanavalin; hepatitis; anti oxidative; oxidative mechanism ... See more keywords
Celastrol pretreatment attenuates concanavalin A‐induced hepatitis in mice by suppressing interleukin‐6/STAT3‐interleukin‐17 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16183
Abstract: Celastrol is extracted from Tripterygium wilfordii Hook F. It has been reported to have protective effects against various liver diseases and immune regulation of autoimmune diseases. However, little is known about whether celastrol protects against… read more here.
Keywords: pretreatment attenuates; celastrol pretreatment; hepatitis; attenuates concanavalin ... See more keywords