Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
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DOI: 10.1691/ph.2020.9935
Abstract: In this study, we investigated the effect of silybin on the pharmacokinetics of brexpiprazole and the underlying mechanism in rats. Two groups of animals received silybin at different doses (50 mg/kg, 25 mg/kg) for 2… read more here.
Keywords: concentration brexpiprazole; blood concentration; cyp3a4 cyp2d6; brexpiprazole ... See more keywords