Evaluation of Deutetrabenazine's Potential to Delay Cardiac Repolarization Using ConcentrationâQTc Analysis
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DOI: 10.1002/cpdd.1161
Abstract: Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate metabolizers (EMs) or poor metabolizers (PMs)… read more here.
Keywords: evaluation; qtc analysis; deutetrabenazine; using concentration ... See more keywords
Exposure-Response Analysis to Assess the Concentration-QTc Relationship of Iberdomide.
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DOI: 10.1002/cpdd.1254
Abstract: Iberdomide is an orally available cereblon-modulating agent being developed for the treatment of hematologic malignancies and autoimmune-mediated diseases. To assess the potential concentration-QTc relationship in humans and to ascertain or exclude a potential QT effect… read more here.
Keywords: iberdomide; concentration; concentration qtc; analysis ... See more keywords