Pharmacokinetics and Concentration-Response of Dupilumab in Patients with Seasonal Allergic Rhinitis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2004
Abstract: Patients with moderate to severe allergic rhinitis may benefit from subcutaneous immunotherapy (SCIT), despite the risk of systemic allergic reaction. Dupilumab is a fully human monoclonal antibody that blocks the shared receptor component for interleukin… read more here.
Keywords: dupilumab; concentration response; allergic rhinitis; seasonal allergic ... See more keywords
Model averaging for robust assessment of QT prolongation by concentration-response analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7395
Abstract: Assessing the QT prolongation potential of a drug is typically done based on pivotal safety studies called thorough QT studies. Model-based estimation of the drug-induced QT prolongation at the estimated mean maximum drug concentration could… read more here.
Keywords: concentration response; model averaging; method; model ... See more keywords
Handling deviating control values in concentration-response curves
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DOI: 10.1007/s00204-020-02913-0
Abstract: In cell biology, pharmacology and toxicology dose-response and concentration-response curves are frequently fitted to data with statistical methods. Such fits are used to derive quantitative measures (e.g. EC\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek}… read more here.
Keywords: concentration response; response; control; control values ... See more keywords
Agonist efficiency from concentration-response curves: structural implications and applications.
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DOI: 10.1016/j.bpj.2021.02.034
Abstract: Agonists are evaluated by a concentration-response curve (CRC), with a midpoint (EC50) that indicates potency, a high-concentration asymptote that indicates efficacy and a low-concentration asymptote that indicates constitutive activity. A third agonist attribute, efficiency (η),… read more here.
Keywords: concentration response; agonist efficiency; concentration asymptote; concentration ... See more keywords
Implications of nonlinearity, confounding, and interactions for estimating exposure concentration-response functions in quantitative risk analysis
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Research"
DOI: 10.1016/j.envres.2020.109638
Abstract: Abstract Recent advances in understanding of biological mechanisms and adverse outcome pathways for many exposure-related diseases show that certain common mechanisms, from ultrasensitive molecular switches in signaling pathways to assembly and activation of inflammasomes to… read more here.
Keywords: exposure concentration; risk; concentration response; response ... See more keywords
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2020.122727
Abstract: In aquatic ecosystems, the biocide triclosan represents a hazard for the non-target microalgae. So far, algal responses were mainly investigated at apical levels hampering the acquisition of a holistic view on primary, adaptive, and compensatory… read more here.
Keywords: multi omics; concentration response; response; chlorophyte scenedesmus ... See more keywords
A fast and reliable test for parallelism in bioassay
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1572615
Abstract: ABSTRACT Parallelism in bioassay is a synonym of similarity between two concentration–response curves. Before the determination of relative potency in bioassays, it is necessary to test for and claim parallelism between the pair of concentration–response… read more here.
Keywords: parallelism; concentration response; method; test ... See more keywords
Concentration-Response Relationships of Dolutegravir and Efavirenz with Weight Change After Starting Antiretroviral Therapy
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DOI: 10.1111/bcp.15177
Abstract: Dolutegravir is associated with more weight gain than efavirenz in people starting antiretroviral therapy (ART). We investigated the concentration–response relationships of efavirenz and dolutegravir with weight gain. We determined concentration–response relationships of dolutegravir and efavirenz… read more here.
Keywords: weight gain; change; concentration response; concentration ... See more keywords
Isolated Human Mesenteric Arteries from Organ Donors as a Model to Determine Arterial Reactivity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5792417
Abstract: Few studies have explored reactivity of isolated human arteries to chemical mediators. The purpose of this research was to establish a model utilizing mesenteric arteries isolated from donated human organs to study tone. The general… read more here.
Keywords: physiology; isolated human; mesenteric arteries; concentration response ... See more keywords
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes
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DOI: 10.1177/24725552211028142
Abstract: A proteolysis-targeting chimera (PROTAC) is a new technology that marks proteins for degradation in a highly specific manner. During screening, PROTAC compounds are tested in concentration–response (CR) assays to determine their potency, and parameters such… read more here.
Keywords: gaussian processes; concentration response; flexible fitting; changepoint gaussian ... See more keywords
A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00168
Abstract: Cell-based assays are an attractive option to measure gene expression response to exposure, but the cost of whole-transcriptome RNA sequencing has been a barrier to the use of gene expression profiling for in vitro toxicity… read more here.
Keywords: gene expression; expression; concentration response; response ... See more keywords