A 3D ecotoxi-topological profile: Using concentration-time-response surfaces to show peroxidase activity in Zea mays (L.) exposed to aluminium or arsenic in hydroponic conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.127647
Abstract: This study sought to use concentration-time-response surfaces to show the effects of exposure to toxic (semi-)metals on peroxidase activity in higher plants as a function of exposure-concentration and exposure-time. Maize (Zea mays L.) seedlings (i.e.,… read more here.
Keywords: concentration time; response surfaces; time; activity ... See more keywords
51Cr-EDTA plasma clearance in children
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DOI: 10.1097/md.0000000000028608
Abstract: Supplemental Digital Content is available in the text Abstract Plasma disappearance curves using multiple blood samples are a recognized reference method for measuring glomerular filtration rate (GFR). However, there is no consensus on the protocol… read more here.
Keywords: time; sample; curve; concentration time ... See more keywords
Limited sampling strategy to predict free mycophenolic acid area under the concentration–time curve in paediatric patients with nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13765
Abstract: In paediatric patients, there is no data on the recommended area under the concentration–time curve from 0 to 12 h (AUC0−12) for free mycophenolic acid (fMPA), which is the active form of the drug, responsible for… read more here.
Keywords: paediatric patients; time; concentration time; area concentration ... See more keywords
Comparison of vancomycin area under the concentration‐time curve (AUC) using two‐point pharmacokinetics versus two open‐access online single‐concentration vancomycin calculators
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DOI: 10.1111/jcpt.13795
Abstract: Current vancomycin monitoring guidelines recommend the use of area under the concentration‐time curve (AUC24) monitoring in patients with serious Methicillin‐Resistant Staphylococcus aureus (MRSA) infections by utilizing either a Bayesian approach or first‐order analytic equations. Several… read more here.
Keywords: vancomycin; concentration time; concentration; open access ... See more keywords
Evaluation of 14-day Concentration-time Curves of Vitamin D3 and 25-Hydroxyvitamin D3 in Healthy Adults With Varying Body Mass Index
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DOI: 10.21873/anticanres.16019
Abstract: Background/Aim: To analyze the concentration-time curves of single-dose oral 25(OH)D3 in comparison with vitamin D3 in healthy adults. Patients and Methods: The pharmacokinetics observed over two weeks after orally administering single 900 μg doses of… read more here.
Keywords: evaluation day; time curves; concentration time; concentration ... See more keywords
Validation of Vancomycin Area under the Concentration—Time Curve Estimation by the Bayesian Approach Using One-Point Samples for Predicting Clinical Outcomes in Patients with Methicillin-Resistant Staphylococcus aureus Infections
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DOI: 10.3390/antibiotics11010096
Abstract: Area under the concentration–time curve (AUC)-guided vancomycin treatment is associated with decreased nephrotoxicity. It is preferable to obtain two samples to estimate the AUC. This study examined the usefulness of AUC estimation via trough concentration… read more here.
Keywords: time; time curve; concentration time; concentration ... See more keywords
Predicting the Area under the Plasma Concentration-Time Curve (AUC) for First Dose Vancomycin Using First-Order Pharmacokinetic Equations
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DOI: 10.3390/antibiotics12040630
Abstract: To treat critically ill patients, early achievement of the target area under the plasma concentration-time curve/minimum inhibitory concentration (AUC/MIC) in the first 24 h is recommended. However, accurately calculating the AUC before steady state is… read more here.
Keywords: vancomycin; auc; concentration time; dose vancomycin ... See more keywords
Damage Effect of Amorphous Carbon Black Nanoparticle Aggregates on Model Phospholipid Membranes: Surface Charge, Exposure Concentration and Time Dependence
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DOI: 10.3390/ijerph20042999
Abstract: Commercial nano-scale carbon blacks (CB) are being harnessed widely and may impose potentially hazardous effects because of their unique properties, especially if they have been modified to grow reactive functional groups on their surface. Cytotoxicity… read more here.
Keywords: carbon; damage; concentration time; mcb ... See more keywords
Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition
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DOI: 10.3390/toxics8010017
Abstract: Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs. Although cell membrane damage has been considered as the main cytotoxic mechanism of BAC,… read more here.
Keywords: concentration time; apoptosis; lung epithelial; benzalkonium chloride ... See more keywords
Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration- and Time-Dependent Manner
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DOI: 10.3390/toxins14030175
Abstract: Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to exert damage at different levels of the organism, it is considered a cytotoxin. Although the main… read more here.
Keywords: concentration time; murine primary; time dependent;