Translating the Concept of Bispecific Antibodies to Engineering Heterodimeric Phosphotriesterases with Broad Organophosphate Substrate Recognition.
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DOI: 10.1021/acs.biochem.0c00751
Abstract: We have adopted the concept of bispecific antibodies, which can simultaneously block or cross-link two different biomolecular targets, to create bispecific enzymes by exploiting the homodimeric quaternary structure of bacterial phosphotriesterases (PTEs). The PTEs from… read more here.
Keywords: bispecific antibodies; concept bispecific; agents pesticides; nerve agents ... See more keywords