Is the concept of clinical equipoise maintained in psoriasis research?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2019.1654596
Abstract: Psoriasis is a chronic autoinflammatory disease which significantly impacts the quality of life of patients. Recently, the therapeutic realm of psoriasis has greatly expanded, with agents offering complete clearance of lesions in up to 37%… read more here.
Keywords: clinical equipoise; placebo; psoriasis; concept clinical ... See more keywords
Single-interface bioelectronic medicines—concept, clinical applications and preclinical data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac6e08
Abstract: Presently, large groups of patients with various diseases are either intolerant, or irresponsive to drug therapies and also intractable by surgery. For several diseases, one option which is available for such patients is the implantable… read more here.
Keywords: clinical applications; concept clinical; interface; single interface ... See more keywords
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial.
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DOI: 10.1097/j.pain.0000000000002675
Abstract: ABSTRACT Translation of promising preclinical efficacy data for investigational analgesics to positive clinical trial outcomes is limited, despite the large collective effort to date. However, one target with positive proof-of-concept clinical trial data is the… read more here.
Keywords: at2 receptor; concept clinical; ema401; trial ... See more keywords
From Concept to Clinical Product: A Brief History of the Novel Shigella Invaplex Vaccine’s Refinement and Evolution
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DOI: 10.3390/vaccines10040548
Abstract: The Shigella invasin complex or Invaplex vaccine is a unique subunit approach to generate a protective immune response. Invaplex is a large, macromolecular complex consisting of the major Shigella antigens: lipopolysaccharide (LPS) and the invasion… read more here.
Keywords: concept clinical; clinical product; shigella; product ... See more keywords