Preclinical and Clinical Proof of Concept for Metabolic Intervention in Diabetic Cardiomyopathy
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DOI: 10.1016/j.cardfail.2019.07.218
Abstract: Introduction Hyperactivation of the polyol pathway (PP) contributes to development of diabetic complications such as diabetic cardiomyopathy (DbCM). Aldose reductase (AR), the rate-controlling enzyme in the PP, catalyzes NADPH-dependent reduction of glucose to sorbitol. Under… read more here.
Keywords: mice; concept metabolic; diabetic cardiomyopathy; proof concept ... See more keywords