Molecular glue concept solidifies
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DOI: 10.1038/s41589-019-0414-3
Abstract: Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4 DCAF15 broaden the mechanistic principles by which molecular… read more here.
Keywords: concept solidifies; molecular glue; glue concept; biology ... See more keywords