A Machine Learning Approach for Handling Big Data Produced by High Resolution Mass Spectrometry after Data Independent Acquisition of Small Molecules - Proof of Concept Study Using an Artificial Neural Network for Sample Classification.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2775
Abstract: Liquid chromatography coupled to high-resolution mass spectrometry (HRMS) enables data independent acquisition (DIA) and untargeted screening. However, to avoid the handling of the resulting large dataset, most laboratories in that field still use targeted screening… read more here.
Keywords: machine; high resolution; machine learning; proof concept ... See more keywords
Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof‐of‐concept study
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DOI: 10.1002/ehf2.13076
Abstract: Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine–isosorbide dinitrate (H‐ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof‐of‐concept study aimed to… read more here.
Keywords: proof concept; cardiorenal syndrome; concept study;
Paradoxical home temperatures during cold weather: a proof-of-concept study
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biometeorology"
DOI: 10.1007/s00484-020-01998-7
Abstract: There is substantial epidemiological evidence on the associations between cold weather and adverse health effects. Meteorological alarm systems are being developed globally, and generalized protective advice is given to the public based on outdoor exposure… read more here.
Keywords: proof concept; concept study; cold weather; controlled apartments ... See more keywords
Wearable haptic anklets for gait and freezing improvement in Parkinson’s disease: a proof-of-concept study
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DOI: 10.1007/s10072-020-04485-4
Abstract: Background and objective In a proof-of-concept study, we aimed to verify whether the wearable haptic anklets, a device that delivers personalized suprathreshold alternating exteroceptive stimulation at the anklets on demand, may improve the quality of… read more here.
Keywords: wearable haptic; haptic anklets; proof concept; concept study ... See more keywords
Proof-of-Concept Study of the NOTI Chelating Platform: Preclinical Evaluation of 64Cu-Labeled Mono- and Trimeric c(RGDfK) Conjugates
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DOI: 10.1007/s11307-020-01530-8
Abstract: Purpose We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three five-membered azaheterocyclic arms for the preparation of 68 Ga- and 64 Cu-based radiopharmaceuticals. Based on this platform, the chelator… read more here.
Keywords: chelating platform; noti tva; rgdfk; proof concept ... See more keywords
Good gamers, good managers? A proof-of-concept study with Sid Meier’s Civilization
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DOI: 10.1007/s11846-020-00378-0
Abstract: Human resource professionals increasingly enhance their assessment tools with game elements—a process typically referred to as “gamification”—to make them more interesting and engaging for candidates, and they design and use “serious games” that can support… read more here.
Keywords: game; proof concept; civilization; concept study ... See more keywords
Biopartitioning micellar electrokinetic chromatography – Concept study of cationic analytes
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DOI: 10.1016/j.microc.2019.104518
Abstract: Abstract In the early stages of drug discovery, beyond the biological activity screening, the physicochemical properties including lipophilicity, ionization, solubility as well as metabolic profiling and protein-binding affinity should be determined for each drug candidate.… read more here.
Keywords: chromatography; electrokinetic chromatography; chromatography concept; concept study ... See more keywords
Norepinephrine may improve survival of septic shock patients in a low-resource setting: a proof-of-concept study on feasibility and efficacy outside the Intensive Care Unit
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2022.2038051
Abstract: ABSTRACT Septic shock treatment in sub-Saharan African hospitals is challenging due to limited availability of ICUs, central venous catheters, vasopressors, and trained staff. We designed this proof-of-concept study to determine efficacy, safety, and feasibility of… read more here.
Keywords: concept study; proof concept; low resource; septic shock ... See more keywords
Thermal Photodynamic Therapy for Actinic Keratoses on Facial Skin: A Proof-of-Concept Study
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DOI: 10.1097/dss.0000000000001702
Abstract: BACKGROUND Warming the skin during the incubation of 5-aminolevulinic acid (ALA) has the potential to improve the efficacy and efficiency of cutaneous photodynamic therapy (PDT) through multiple mechanisms. The aim of this proof-of-concept study is… read more here.
Keywords: facial skin; concept study; proof concept; incubation ... See more keywords
Tele‐pharmacy in rural Scotland: a proof of concept study
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DOI: 10.1111/ijpp.12376
Abstract: Technology enables medical services to be provided to rural communities. This proof of concept study assessed the feasibility and acceptability of delivering community pharmacy services (CPS; including advice, sale of over‐the‐counter products and dispensing of… read more here.
Keywords: proof concept; tele pharmacy; concept study;
Magnetic Resonance Imaging for Monitoring of Hepatic Disease Induced by Ebola Virus: a Nonhuman Primate Proof-of-Concept Study
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03538-22
Abstract: Severe liver impairment is a well-known hallmark of Ebola virus disease (EVD), but the contribution of hepatic pathophysiology to EVD progression is not fully understood. Noninvasive medical imaging of liver structure and function in well-established… read more here.
Keywords: concept study; proof concept; liver; disease ... See more keywords