Concise synthesis of 1-epi-castanospermine
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2017.05.013
Abstract: Abstract 1-epi-Castanospermine (5) was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin (11) in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps. read more here.
Keywords: concise synthesis; synthesis epi; castanospermine; epi castanospermine ... See more keywords
Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100840
Abstract: Summary A highly efficient phosphine-catalyzed enantioselective [4 + 2] annulation of allenoates with 3-nitroindoles or 3-nitrobenzothiophenes has been developed. The protocol represents a unique dearomatization–aromatization process to access functionalized dihydrocarbazoles or dihydrodibenzothiophenes with high optical… read more here.
Keywords: annulation; concise synthesis; synthesis chiral; enantioselective annulation ... See more keywords
A concise synthesis of carbasugars isolated from Streptomyces lincolnensis
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131346
Abstract: Abstract (−)-Quinic acid was used as a starting material in the hemisynthesis of two epimeric carbasugars isolated from Streptomyces lincolnensis. Previous 10–12 steps syntheses for the carbasugars have been herein shortened to 4–6 steps by… read more here.
Keywords: synthesis carbasugars; isolated streptomyces; concise synthesis; carbasugars isolated ... See more keywords
Concise Synthesis of 7-Deoxypsammaplysins K and O and 7-Deoxyceratinamide A by 1,3-Dipole Cycloaddition.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01298
Abstract: A spiro-oxepin isoxazoline skeleton was constructed via 1,3-dipole cycloaddition as a key step, which enabled the total syntheses of 7-deoxyceratinamide A and 7-deoxypsammaplysins K and O. The developed chemistry could be applied to total synthesis… read more here.
Keywords: dipole cycloaddition; cycloaddition; concise synthesis; synthesis deoxypsammaplysins ... See more keywords
Concise Synthesis of Tetrazole Macrocycle
Sign Up to like & getrecommendations! Published in 2017 at "Organic Letters"
DOI: 10.1021/acs.orglett.7b02319
Abstract: A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford… read more here.
Keywords: concise synthesis; tetrazole macrocycle; synthesis tetrazole; synthesis ... See more keywords
Concise Synthesis of (S)-δ-CEHC, a Metabolite of Vitamin E
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c05658
Abstract: Carboxyethyl hydroxychromans (CEHCs) are natural metabolites of vitamin E (VE). Their urinary levels can serve as useful biomarkers for the nutritional assessment of VE. Moreover, specific biological activities of CEHCs deserve further investigation. Here, we… read more here.
Keywords: concise synthesis; concise; cehc metabolite; synthesis cehc ... See more keywords
A Concise Synthesis of Pleurotin Enabled by a Nontraditional C-H Epimerization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06504
Abstract: An 8-step synthesis of a known pentacyclic intermediate toward the natural product pleurotin (1) is described. Pleurotin and related benzoquinone natural products are of great interest for their powerful anticancer and antibiotic activities. The route… read more here.
Keywords: synthesis pleurotin; epimerization; pleurotin enabled; synthesis ... See more keywords
A concise synthesis and biological study of evodiamine and its analogues.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc00434c
Abstract: Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance… read more here.
Keywords: concise synthesis; biological study; evodiamine; synthesis biological ... See more keywords
The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C–H activation
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra01075e
Abstract: Planar chiral [2.2]paracyclophanes are resolved through the direct C–H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane… read more here.
Keywords: chiral paracyclophane; planar chiral; paracyclophane; synthesis resolution ... See more keywords
A concise synthesis of 2-benzoyl-1-indanones and 1-indanones from 2-aryl-1-tetralones
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1771370
Abstract: Abstract Methyl-2-(3-oxo-3-aryl) benzoates derived from acid catalyzed air oxidative fragmentation of 2-aryl-1-tetralones were efficiently undergone intramolecular-Claisen condensation in the presence of potassium tertiary butoxide. The resulting 2-benzoyl-1-indanones formed in two-step ring contractions were further subjected… read more here.
Keywords: concise synthesis; indanones aryl; benzoyl indanones; synthesis benzoyl ... See more keywords
Concise synthesis of marine natural products smenodiol and (−)-pelorol
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2021.2023871
Abstract: Abstract A facile synthesis of marine natural product smenodiol has been achieved in 23.2% overall yield within 8 steps from readily available starting materials, which facilitates a concise synthesis of the marine natural product (−)-pelorol… read more here.
Keywords: marine natural; pelorol; concise synthesis; natural product ... See more keywords