Concise Total Synthesis of Peyssonnoside A.
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DOI: 10.1021/jacs.1c07135
Abstract: Peyssonnoside A is a marine-derived sulfated diterpenoid glucoside with a unique 5/6/3/6 tetracyclic skeleton with a highly substituted cyclopropane ring deeply embedded into the structure. Herein, we report the first total synthesis of this natural… read more here.
Keywords: total synthesis; synthesis peyssonnoside; concise total; synthesis ... See more keywords
Concise total syntheses of phelligridins A, C, and D
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DOI: 10.1039/c8ra10346a
Abstract: We have established a concise and scalable synthetic pathway for phelligridins A (1), C (2) and D (3) by using Suzuki–Miyamura coupling and aldol-type condensation as key steps. read more here.
Keywords: total syntheses; syntheses phelligridins; concise total;
Concise Total Syntheses of Paullone and Kenpaullone via Cyanide-Catalyzed Intramolecular Imino-Stetter Reaction
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DOI: 10.1055/s-0036-1588749
Abstract: Highly concise total syntheses of paullone and kenpaullone were developed. Cyanide-catalyzed intramolecular imino-Stetter reaction of aldimines derived from methyl 2-aminocinnamate derivatives and 2-nitrobenzaldehyde provided 2-(2′-nitrophenyl)indole-3-acetic acid derivatives. Subsequent reduction of the nitro group with zinc… read more here.
Keywords: total syntheses; concise total; cyanide catalyzed; paullone kenpaullone ... See more keywords
Concise Total Synthesis of (+)-Aphanorphine
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DOI: 10.1055/s-0037-1610769
Abstract: A concise total synthesis of (+)-aphanorphine is described. The key features of the strategy include a Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition to form ring C and a Co-catalyzed radical cyclization through a hydrogen-atom transfer to close… read more here.
Keywords: synthesis aphanorphine; total synthesis; synthesis; concise total ... See more keywords
Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
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DOI: 10.3390/molecules25173859
Abstract: The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on… read more here.
Keywords: fusaric acid; concise total; total synthesis; natural product ... See more keywords