Effect of Itraconazole or Rifampin on Zilurgisertib Pharmacokinetics When Administered Orally in Healthy Participants
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DOI: 10.1002/cpdd.1553
Abstract: Zilurgisertib is an oral, activin receptor‐like kinase 2 (ALK2) inhibitor being developed for the treatment of patients with fibrodysplasia ossificans progressiva. In vitro metabolism studies suggest zilurgisertib is primarily eliminated via cytochrome P450 (CYP) 3A4/5‐mediated… read more here.
Keywords: healthy participants; concomitant administration; drug; zilurgisertib ... See more keywords
Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na+/K+-ATPase
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DOI: 10.1080/13813455.2018.1437752
Abstract: Abstract This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control,… read more here.
Keywords: insulin; resveratrol; mechanism; res insulin ... See more keywords
Safety implications of concomitant administration of antidepressants and opioid analgesics in surgical patients.
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DOI: 10.1080/14740338.2023.2181333
Abstract: BACKGROUND Commonly prescribed antidepressants (paroxetine, fluoxetine, duloxetine, bupropion) inhibit bioconversion of several prodrug opioid medications to their active metabolite, potentially decreasing analgesic effect. There is a paucity of studies assessing the risk-benefit of concomitant administration… read more here.
Keywords: administration antidepressants; safety; concomitant administration; risk ... See more keywords
Concomitant Administration of Red Ginseng Extract with Lactic Acid Bacteria Increases the Plasma Concentration of Deglycosylated Ginsenosides in Healthy Human Subjects
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DOI: 10.3390/biom12121896
Abstract: With the increased frequency of red ginseng extract (RGE) and lactic acid bacteria (LAB) co-administration, we aimed to investigate the interactions between RGE and LAB with regard to in vitro and in vivo deglycosylation metabolism… read more here.
Keywords: administration; concomitant administration; ginseng extract; lactic acid ... See more keywords