Sperm chromatin condensation defects, but neither DNA fragmentation nor aneuploidy, are an independent predictor of clinical pregnancy after intracytoplasmic sperm injection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-019-01471-4
Abstract: PurposeThe impact of sperm DNA damage on intracytoplasmic sperm injection (ICSI) outcomes remains controversial. The purpose of the study was to evaluate the prognostic value of several types of sperm nuclear damage on ICSI clinical… read more here.
Keywords: pregnancy; dna fragmentation; clinical pregnancy; condensation defects ... See more keywords
An illustration of human sperm morphology and their functional ability among different group of subfertile males
Sign Up to like & getrecommendations! Published in 2018 at "Andrology"
DOI: 10.1111/andr.12500
Abstract: Condensed sperm chromatin is a prerequisite for natural fertilization. Some reports suggested the prevalence of chromatin condensation defects in teratozoospermia cases with head anomalies; conversely, earlier studies exemplified its occurrence in morphologically normal spermatozoa too.… read more here.
Keywords: fertilization; microscopy; sperm; condensation defects ... See more keywords
Detecting Chromosome Condensation Defects in Gulf War Illness Patients
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DOI: 10.2174/1389202918666170705150819
Abstract: Background: Gulf War Illness (GWI) impacts 25-30% of gulf war veterans. Due to its heterogeneity in both etiology and symptoms, it has been challenging to establish the commonly accepted case definition for GWI. Equally challenging… read more here.
Keywords: gulf war; gwi patients; condensation; chromosome condensation ... See more keywords
Oxidative Stress Is Associated with Telomere Interaction Impairment and Chromatin Condensation Defects in Spermatozoa of Infertile Males
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DOI: 10.3390/antiox10040593
Abstract: Telomere length can be influenced by reactive oxygen species (ROS) generated by lifestyle factors or environmental exposure. We sought to determine whether oxidative stress has an impact on sperm nuclear alterations, especially on chromatin organization… read more here.
Keywords: oxidative stress; condensation defects; infertile males; chromatin condensation ... See more keywords