Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains.
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DOI: 10.1021/acschembio.2c00474
Abstract: Nonribosomal peptide synthetases (NRPSs) are a family of multidomain enzymes dedicated to the production of peptide natural products. Central to NRPS function are condensation (C) domains, which catalyze peptide bond formation and a number of… read more here.
Keywords: trapping late; nonribosomal peptide; late stage; condensation domains ... See more keywords