Condensin Regulation of Genome Architecture
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25702
Abstract: Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied… read more here.
Keywords: interphase; condensin; genome architecture; condensin regulation ... See more keywords
Efficient Depletion of Fission Yeast Condensin by Combined Transcriptional Repression and Auxin-Induced Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9520-2_3
Abstract: Structural maintenance of chromosomes (SMC) complexes play pivotal roles in controlling chromatin organization. Condensin is an essential SMC complex that compacts chromatin to form condensed chromosomes in mitosis. Complete condensin inactivation is necessary to reveal… read more here.
Keywords: repression auxin; condensin; depletion; fission yeast ... See more keywords
Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13604-5
Abstract: Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D genome reorganization. Here,… read more here.
Keywords: gene regulation; reorganization; condensin; senescence ... See more keywords
DNA-loop extruding condensin complexes can traverse one another
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2067-5
Abstract: Condensin, a key component of the structure maintenance of chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA 1 . It remains unclear, however, how condensin complexes… read more here.
Keywords: loop extruding; dna; condensin; condensin complexes ... See more keywords
Suppressor screening reveals common kleisin–hinge interaction in condensin and cohesin, but different modes of regulation
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1902699116
Abstract: Significance Condensin and cohesin are heteropentameric complexes containing two structural maintenance of chromosomes (SMC) subunits and three non-SMC subunits. SMC dimers form head and hinge domains connected by long coiled coils. Suppressor screening for head-associated… read more here.
Keywords: head; kleisin; hinge; condensin ... See more keywords
HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e15-12-0843
Abstract: Condensin II interacts with human CENP-A chaperone HJURP and is present at centromeres in early G1. Condensin II, but not condensin I, is required for efficient CENP-A deposition in human cells. HJURP-induced chromatin decondensation at… read more here.
Keywords: hjurp interaction; hjurp; condensin; cenp deposition ... See more keywords
Condensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac802
Abstract: Abstract Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles… read more here.
Keywords: condensin condensin; condensin; dependent super; line ... See more keywords
Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
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DOI: 10.1101/2021.03.23.436694
Abstract: Condensins are molecular motors that compact DNA via linear translocation. In C. elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC). Condensin DC is recruited to and spreads from a small… read more here.
Keywords: anchored tads; condensin; rex; rex sites ... See more keywords
Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays
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DOI: 10.1101/2022.04.04.487030
Abstract: In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Despite recent progress in our understanding of the mechanism of action of condensin I, how condensin II might work has remained… read more here.
Keywords: condensin; cap; condensin mediated; chromosome assembly ... See more keywords
The Condensin II Subunit, NcapH2, Is Required for Proper Embryonic Erythroid Terminal Maturation and Embryonic Viability in a Primary Mouse Model
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127353
Abstract: The process of nuclear condensation is an integral part of erythroid differentiation. We have previously shown that loss of the histone methyltransferase, Setd8, results in severe embryonic (primitive) erythroid anemia due to loss of chromatin… read more here.
Keywords: condensation; condensin; erythroid terminal; maturation ... See more keywords
Structural basis of HEAT‐kleisin interactions in the human condensin I subcomplex
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DOI: 10.15252/embr.201847183
Abstract: Condensin I is a multi‐protein complex that plays an essential role in mitotic chromosome assembly and segregation in eukaryotes. It is composed of five subunits: two SMC (SMC2 and SMC4), a kleisin (CAP‐H), and two… read more here.
Keywords: human condensin; hcap; kleisin; condensin ... See more keywords