Complex modifier landscape underlying genetic background effects
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1820915116
Abstract: Significance Genetic background impacts the phenotypic outcome of a mutation in different individuals; however, the underlying molecular mechanisms are often unclear. We characterized genes exhibiting conditional essentiality when mutated in two genetically distinct yeast strains.… read more here.
Keywords: complex modifier; genetic background; conditional essentiality; gene ... See more keywords
Plasticity and conditional essentiality of modification enzymes for domain V of Escherichia coli 23S ribosomal RNA
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DOI: 10.1261/rna.079096.121
Abstract: Escherichia coli rRNAs are post-transcriptionally modified at 36 positions but their modification enzymes are dispensable individually for growth, bringing into question their significance. However, a major growth defect was reported for deletion of the RlmE… read more here.
Keywords: modification; conditional essentiality; escherichia coli; knockout ... See more keywords