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   Articles with "conditional knockout" as a keyword



A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor.

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recommendations! Published in 2023 at "Genesis"

DOI: 10.1002/dvg.23515

Abstract: Early growth response 1 (EGR1) mediates transcriptional programs that are indispensable for cell division, differentiation, and apoptosis in numerous physiologies and pathophysiologies. Whole-body EGR1 knockouts in mice (Egr1KO ) have advanced our understanding of EGR1… read more here.

Keywords: growth response; crispr cas9; early growth; mouse ... See more keywords

Generation of an Armcx1 Conditional Knockout Mouse

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recommendations! Published in 2024 at "genesis"

DOI: 10.1002/dvg.23615

Abstract: Armadillo repeat‐containing X‐linked protein‐1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell… read more here.

Keywords: generation armcx1; armcx1 conditional; conditional knockout; knockout mouse ... See more keywords

Co-variation of Host Gene Expression and Gut Microbiome in Intestine-Specific Spp1 Conditional Knockout Mice

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recommendations! Published in 2025 at "Current Microbiology"

DOI: 10.1007/s00284-025-04246-6

Abstract: Osteopontin, which is a highly phosphorylated and glycosylated acidic secreted protein encoded by the secreted phosphoprotein 1 (Spp1) gene, plays a crucial role in immune regulation, inflammatory responses, and cell adhesion. However, its impact on… read more here.

Keywords: host; gene expression; conditional knockout; expression ... See more keywords

Dysregulation of humoral immunity in Foxp3 conditional-knockout mice.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.090

Abstract: Foxp3+ regulatory T cells (Tregs) are crucial for maintaining tolerance to self-antigens and preventing autoimmune diseases. Loss of Foxp3 expression leads to autoimmunity and disrupts humoral immune responses, including hyperproduction of immunoglobulin E (IgE). Elucidation… read more here.

Keywords: foxp3floxr26creert2 mice; humoral immunity; knockout mice; mice ... See more keywords

Conditional Knockout of Ankyrin-G In The Mouse Forebrain Results In Bipolar-Like Behavior

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recommendations! Published in 2017 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2016.09.574

Abstract: Background To date, few animal models of bipolar disorder have been developed, and fewer still are based on genetic loci despite the fact that genome wide association studies (GWAS) have now identified a number of… read more here.

Keywords: social defeat; mice; ankyrin; conditional knockout ... See more keywords

A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00654-2

Abstract: The most powerful way to probe protein function is to characterize the consequence of its deletion. Compared to conventional gene knockout (KO), conditional knockout (cKO) provides an advanced gene targeting strategy with which gene deletion… read more here.

Keywords: targeting multiple; multiple genes; strategy; conditional knockout ... See more keywords

A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.adf2695

Abstract: Hundreds of pathogenic variants of mitochondrial DNA (mtDNA) have been reported to cause mitochondrial diseases, which still lack effective treatments. It is a huge challenge to install these mutations one by one. We repurposed the… read more here.

Keywords: rat; stop codon; premature stop; coding genes ... See more keywords

Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis

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recommendations! Published in 2022 at "Circulation"

DOI: 10.1161/circulationaha.121.058777

Abstract: Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and… read more here.

Keywords: sinoatrial node; yap; hippo; hippo signaling ... See more keywords

Multiple Gene Transfer and All-In-One Conditional Knockout Systems in Mouse Embryonic Stem Cells for Analysis of Gene Function

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.870629

Abstract: Mouse embryonic stem cells (ESCs) are powerful tools for functional analysis of stem cell-related genes; however, complex gene manipulations, such as locus-targeted introduction of multiple genes and conditional gene knockout conditional knockout, are technically difficult.… read more here.

Keywords: embryonic stem; mouse embryonic; stem; gene ... See more keywords

Proteomic profiling of eIF3a conditional knockout mice

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recommendations! Published in 2023 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2023.1160063

Abstract: Eukaryotic translation initiation factor 3 subunit A (eIF3a) is the largest subunit of the eukaryotic translation initiation factor 3 (eIF3). eIF3a plays an integral role in protein biosynthesis, hence impacting the onset, development, and treatment… read more here.

Keywords: signaling pathway; knockout; knockout mice; eif3a conditional ... See more keywords

NaV1.1 is essential for proprioceptive signaling and motor behaviors

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recommendations! Published in 2022 at "eLife"

DOI: 10.7554/elife.79917

Abstract: The voltage-gated sodium channel (NaV), NaV1.1, is well-studied in the central nervous system; conversely, its contribution to peripheral sensory neuron function is more enigmatic. Here, we identify a new role for NaV1.1 in mammalian proprioception.… read more here.

Keywords: nav1 essential; knockout; proprioceptive signaling; motor ... See more keywords