Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy
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DOI: 10.1002/acn3.52010
Abstract: Canavan disease is a leukodystrophy caused by ASPA mutations that diminish oligodendroglial aspartoacylase activity, and is characterized by markedly elevated brain concentrations of the aspartoacylase substrate N‐acetyl‐l‐aspartate (NAA) and by astroglial and intramyelinic vacuolation. Astroglia… read more here.
Keywords: astroglial conditional; canavan; canavan disease; conditional slc13a3 ... See more keywords