Inherently and Conditionally Essential Protein Catabolism Genes of Porphyromonas gingivalis.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.09.002
Abstract: Proteases are critical virulence determinants of Porphyromonas gingivalis, an emerging Alzheimer's disease, cancer, and arthritis pathogen and established agent of periodontitis. Transposon sequencing has been employed to define the core essential genome of this bacterium… read more here.
Keywords: catabolism genes; conditionally essential; protein catabolism; porphyromonas gingivalis ... See more keywords
Flux-Balance Analysis and Mobile CRISPRi-Guided Deletion of a Conditionally Essential Gene in Shewanella oneidensis MR-1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00323
Abstract: Carbon-neutral production of valuable bioproducts is critical to sustainable development but remains limited by the slow engineering of photosynthetic organisms. Improving existing synthetic biology tools to engineer model organisms to fix carbon dioxide is one… read more here.
Keywords: essential gene; deletion; conditionally essential; gene ... See more keywords
Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: where we stand
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2077328
Abstract: ABSTRACT Introduction Several decades of antitubercular drug discovery efforts have focused on novel antitubercular chemotherapies. However, recent efforts have greatly shifted toward countering extremely/multi/total drug-resistant species. Targeting the conditionally essential elements inside Mycobacterium is a… read more here.
Keywords: drug discovery; iron; approaches targeting; conditionally essential ... See more keywords
Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14091987
Abstract: L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids. A hydroxyl side-chain of… read more here.
Keywords: serine metabolism; essential amino; serine; conditionally essential ... See more keywords