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   Articles with "conditionally essential" as a keyword



Inherently and Conditionally Essential Protein Catabolism Genes of Porphyromonas gingivalis.

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recommendations! Published in 2020 at "Trends in microbiology"

DOI: 10.1016/j.tim.2020.09.002

Abstract: Proteases are critical virulence determinants of Porphyromonas gingivalis, an emerging Alzheimer's disease, cancer, and arthritis pathogen and established agent of periodontitis. Transposon sequencing has been employed to define the core essential genome of this bacterium… read more here.

Keywords: catabolism genes; conditionally essential; protein catabolism; porphyromonas gingivalis ... See more keywords

Flux-Balance Analysis and Mobile CRISPRi-Guided Deletion of a Conditionally Essential Gene in Shewanella oneidensis MR-1.

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recommendations! Published in 2022 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00323

Abstract: Carbon-neutral production of valuable bioproducts is critical to sustainable development but remains limited by the slow engineering of photosynthetic organisms. Improving existing synthetic biology tools to engineer model organisms to fix carbon dioxide is one… read more here.

Keywords: essential gene; deletion; conditionally essential; gene ... See more keywords

Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: where we stand

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recommendations! Published in 2022 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2022.2077328

Abstract: ABSTRACT Introduction Several decades of antitubercular drug discovery efforts have focused on novel antitubercular chemotherapies. However, recent efforts have greatly shifted toward countering extremely/multi/total drug-resistant species. Targeting the conditionally essential elements inside Mycobacterium is a… read more here.

Keywords: drug discovery; iron; approaches targeting; conditionally essential ... See more keywords

Abstract 6606: HK2 is conditionally essential for growth in human cancer cells

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-6606

Abstract: The genetic drivers of cell growth can depend on an interplay of intrinsic factors and environmental context. However, there is often little consideration into how nutrient availability affects the genetic dependencies of proliferating human cells.… read more here.

Keywords: cancer; hk2 knockout; conditionally essential; hk2 ... See more keywords

Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid

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recommendations! Published in 2022 at "Nutrients"

DOI: 10.3390/nu14091987

Abstract: L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids. A hydroxyl side-chain of… read more here.

Keywords: serine metabolism; essential amino; serine; conditionally essential ... See more keywords