Similar outcome of allogeneic stem cell transplantation after myeloablative and sequential conditioning regimen in patients with refractory or relapsed acute myeloid leukemia: A study from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire
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DOI: 10.1002/ajh.25004
Abstract: Patients with acute myeloid leukemia (AML) in relapse or refractory to induction therapy have a dismal prognosis. Allogeneic hematopoietic stem cell transplantation is the only curative option. In these patients, we aimed to compare the… read more here.
Keywords: refractory relapsed; myeloid leukemia; stem cell; conditioning regimen ... See more keywords
Thiotepa, busulfan and fludarabine compared to busulfan and cyclophosphamide as conditioning regimen for allogeneic stem cell transplant from matched siblings and unrelated donors for acute myeloid leukemia
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DOI: 10.1002/ajh.25225
Abstract: Busulfan plus cyclophosphamide (BuCy) is the traditional conditioning regimen for allogeneic stem cell transplant (allo‐SCT) for young, fit patients with acute myeloid leukemia (AML). The thiotepa‐busulfan‐fludarabine (TBF) protocol has recently demonstrated promising outcome in cord… read more here.
Keywords: busulfan; regimen allogeneic; transplant; conditioning regimen ... See more keywords
Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI
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DOI: 10.1002/hon.3046
Abstract: The medium‐dose etoposide (VP16) added on cyclophosphamide (CY)/total body irradiation (TBI) is one of the intensified myeloablative conditioning regimens used in allogenic hematopoietic stem cell transplantation (allo‐HSCT) for acute lymphoblastic leukemia (ALL). However, the patient… read more here.
Keywords: vp16 tbi; conditioning regimen; medium dose; adult ... See more keywords
Cladribine‐ and decitabine‐containing conditioning regimen has a low post‐transplant relapse rate in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome
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DOI: 10.1002/ijc.34419
Abstract: To reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation (allo‐HSCT), there have been continuing efforts to optimize the conditioning regimens. Our study aimed to analyze the risk factors associated with the relapse… read more here.
Keywords: aml high; cladribine; high risk; relapse ... See more keywords
Intravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients with multiple myeloma
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DOI: 10.1007/s00277-019-03663-5
Abstract: Dear Editor, To improve results in transplant-eligible multiple myeloma (MM) patients, the combination of busulfan and melphalan (BUMEL) has been used as an alternative conditioning regimen to standard-dose melphalan 200 mg/m (MEL200) [1–4]. The results… read more here.
Keywords: busulfan; bumel; control; multiple myeloma ... See more keywords
Busulfan-cyclophosphamide versus cyclophosphamide-busulfan as conditioning regimen before allogeneic hematopoietic cell transplantation: a prospective randomized trial
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DOI: 10.1007/s00277-020-04312-y
Abstract: Busulfan and cyclophosphamide (BuCy) is a frequently used myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT). Theoretical considerations and pharmacological data indicate that application of busulfan prior to subsequent cyclophosphamide (BuCy) may trigger liver… read more here.
Keywords: busulfan; regimen allogeneic; allogeneic hematopoietic; conditioning regimen ... See more keywords
Conditioning regimen with a 75% dose of standard busulfan/cyclophosphamide plus fludarabine before cord blood transplantation in older patients with AML and MDS
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DOI: 10.1007/s12185-019-02688-w
Abstract: In this retrospective study, we aimed to establish a conditioning regimen for older patients receiving cord blood transplantation (CBT). This study included 21 older patients [median age 65 (58–73) years] with acute myeloid leukemia and myelodysplastic… read more here.
Keywords: older patients; cord blood; conditioning regimen; blood transplantation ... See more keywords
Feasibility of an intensified myeloablative conditioning regimen consisting of busulfan, fludarabine, cytarabine, and total body irradiation before single cord blood transplantation in elderly patients
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DOI: 10.1007/s12185-021-03131-9
Abstract: The optimal conditioning regimen for stem cell transplantation in elderly patients remains to be established. We developed a novel preparative regimen using fludarabine 180 mg/m2, intravenous busulfan 12.8 mg/m2, cytarabine 8 g/m2, and 4-Gy total… read more here.
Keywords: transplantation elderly; disease; elderly patients; transplantation ... See more keywords
Conditioning Regimen [High-Dose Melphalan (HDM) Versus an Alternative] May Impact Response in Patients (pts) with Relapsed Multiple Myeloma (rMM) Receiving a Second Autologous Stem Cell Transplant (AutoSCT)
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DOI: 10.1016/j.bbmt.2018.12.345
Abstract: Introduction Second AutoSCT has been demonstrated to be beneficial in pts with relapsed multiple myeloma (rMM), in clinical trials. The optimal conditioning regimen for pts who receive a second transplant has not been currently established.… read more here.
Keywords: response; rmm; hdm; second autosct ... See more keywords
Influence of the Intensity of the Allogeneic Conditioning Regimen on the Risk of Hemorrhagic Cystitis (HC) in Patients Receiving Post- Transplant Cyclophosphamide (PT-Cy) As Gvhd Prophylaxis
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DOI: 10.1016/j.bbmt.2018.12.441
Abstract: Background Our group previously reported a 16% incidence of HC after hematopoietic cell transplantation (HCT) involving mostly matched unrelated donors (85%) and ATG-containing regimens (80%) (Silva, Haematologica 2010). PT-Cy is an effective GVHD prophylaxis in… read more here.
Keywords: gvhd prophylaxis; conditioning regimen; cystitis; group ... See more keywords
High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma
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DOI: 10.1038/bmt.2017.208
Abstract: Single-agent high-dose melphalan (HDM, 200 mg/m2) has been the most commonly used conditioning regimen prior to autologous stem cell transplant, since its introduction in 1992. We used a more aggressive alkylator-based conditioning regimen in an attempt… read more here.
Keywords: bcnu hdm; high dose; stem cell; conditioning regimen ... See more keywords