Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total‐body irradiation or treosulfan‐based conditioning regimens
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DOI: 10.1002/rmb2.12648
Abstract: Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan‐based… read more here.
Keywords: cell transplantation; hematopoietic stem; stem cell; fertility ... See more keywords
Total body irradiation as part of conditioning regimens in childhood leukemia—long-term outcome, toxicity, and secondary malignancies
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DOI: 10.1007/s00066-021-01810-4
Abstract: Total body irradiation (TBI) is an established part of conditioning regimens prior to stem cell transplantation in childhood leukemia but is associated with long-term toxicity. We retrospectively analyzed survival, long-term toxicity, and secondary malignancies in… read more here.
Keywords: term; secondary malignancies; total body; long term ... See more keywords
Current status of conditioning regimens in haploidentical hematopoietic cell transplantation
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DOI: 10.1080/16078454.2024.2332866
Abstract: ABSTRACT The development of effective prophylaxis strategies against graft-versus-host disease (GVHD) has contributed to the widespread use of haploidentical related hematopoietic cell transplantation (Haplo-HCT). Currently, GVHD prophylaxis containing posttransplant cyclophosphamide (PTCY) is considered the standard… read more here.
Keywords: hematopoietic cell; hct; conditioning; haplo hct ... See more keywords
Can we improve the conditioning regimen before autologous stem cell transplantation in multiple myeloma?
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DOI: 10.1080/21678707.2017.1387050
Abstract: ABSTRACT Introduction: High-Dose Chemotherapy and Autologous Stem Cell Transplantation (ASCT) has long been established as the standard of care for eligible patients with newly diagnosed multiple myeloma. Although many studies have been performed in the… read more here.
Keywords: cell transplantation; multiple myeloma; stem cell; conditioning regimen ... See more keywords
Abstract 511: An assessment of pre-conditioning regimens for optimal hCD34+ hematopoietic stem cell humanization of NSGTMmice
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DOI: 10.1158/1538-7445.am2019-511
Abstract: Humanized immune system (HIS) mice - immunocompromised Nod.Cg-PrkdcscidIl2rgtm1Wjl/SzJ animals in which the immune system has been humanized by the engraftment of CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), or other human cells/tissues… read more here.
Keywords: pre; conditioning regimens; hcd34; pre conditioning ... See more keywords
A Retrospective Observation of Treatment Outcomes Using Decitabine-Combined Standard Conditioning Regimens Before Transplantation in Patients With Relapsed or Refractory Acute Myeloid Leukemia
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DOI: 10.3389/fonc.2021.702239
Abstract: Hypomethylating agents, decitabine (DAC) and azacitidine, can act as prophylactic and pre-emptive approaches after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a non-intensive bridging approach before allo-HSCT. However, they are rarely used as a part… read more here.
Keywords: relapsed refractory; standard conditioning; conditioning regimens; leukemia ... See more keywords